Effect of defibrillation pulses of different shapes on biomembranes: experimental study

We studied the effects of high-voltage single, double unipolar, and double bipolar electric pulses of exponential or sine shape on erythrocyte membranes. Either single or double (mono- or bipolar) pulses were used. All pulses electroporated the membranes, and the electroporation threshold did not de...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 137; no. 2; pp. 120 - 123
Main Authors:	Moroz, V V, Bogushevich, M S, Chernysh, A M, Kozlova, E K, Sharakshane, A S
Format:	Journal Article
Language:	English Russian
Published:	United States Springer Nature B.V 01-02-2004
Subjects:	Electric Countershock - adverse effects Electric Countershock - methods Electrophysiology Electroporation Erythrocyte Membrane - physiology Hemolysis Humans In Vitro Techniques Kinetics
Online Access:	Get full text
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Summary:	We studied the effects of high-voltage single, double unipolar, and double bipolar electric pulses of exponential or sine shape on erythrocyte membranes. Either single or double (mono- or bipolar) pulses were used. All pulses electroporated the membranes, and the electroporation threshold did not depend on the pulse shape. Two successive pulses decreased erythrocyte number in a nonadditive way. Similar to defibrillation of the whole heart, the effect of two bipolar pulses on erythrocytes was more pronounced than the effect of two unipolar pulses.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1023/B:BEBM.0000028118.86481.f6