The role of clusterin in tissue injury

The role of clusterin in tissue injury

Clusterin is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and...

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Bibliographic Details
Published in:Biochemistry and cell biology Vol. 72; no. 11-12; p. 483
Main Authors: Silkensen, J R, Schwochau, G B, Rosenberg, M E
Format: Journal Article
Language:English
Published: Canada 01-11-1994
Subjects:
Animals
Apoptosis
Cell Communication
Clusterin
Disease
Glycoproteins - physiology
Humans
Molecular Chaperones
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Summary:Clusterin is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. The expression of clusterin in these states is intriguing given the apparent incongruity of the conditions listed, the variety of stimuli eliciting such expression, and the multiple proposed roles once induced. This review will outline the conditions associated with clusterin induction and speculate on its role in disease.
ISSN:0829-8211
DOI:10.1139/o94-065