Influence of dietary fermented Saccharomyces cerevisiae on growth performance, oxidative stress parameters, and immune response of cultured Oreochromis niloticus

• Published in: Fish physiology and biochemistry Vol. 46; no. 2; pp. 533 - 545
• Main Authors: Abu-Elala, Nermeen M., Younis, Nehal A., AbuBakr, Huda O., Ragaa, Naela M., Borges, Liliana L., Bonato, Melina A.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-04-2020; Springer Nature B.V
• Subjects: Animal Anatomy; Animal Biochemistry; Animal Physiology; Antioxidants; Bacteria; Biomedical and Life Sciences; Catalase; Control; Defence mechanisms; Diet; Dietary supplements; Ecological aggregations; Feed conversion; Feeding experiments; Fermentation; Fermented food; Fish; Freshwater & Marine Ecology; Gene expression; Glutathione; Glutathione reductase; Gram-positive bacteria; Growth; Histology; IL-1β; Immune response; Immune system; Immunity; Immunology; Intestine; Intestines; Kidneys; Life Sciences; Liver; Lysozyme; Marine fishes; Morphology; Oreochromis niloticus; Oxidants; Oxidative stress; Oxidizing agents; Parameters; Phagocytes; Reductases; Spleen; Tumor necrosis factor-α; Yeasts; Zoology; Nucleotides; β-Glucans; Growth; Immunity; Challenge; O. niloticus
• ISSN: 0920-1742; 1573-5168
• DOI: 10.1007/s10695-019-00711-9

Our trial was performed to investigate the effect of fully fermented yeast
Sacharomyces cerevisiae
(Hilyses, ICC Company, Brazil) on the growth performance and immune response of
Oreochromis niloticus
. In this study, a total of 270
O. niloticus
(50.7 ± 0.8 g) were randomly divided into 3 groups in triplicates. The control group was fed on the basal diet while the other two groups were fed on a basal diet supplemented with 0.2% and 0.4% of Hilyses. The trial period extended for 2 months. At the end of the feeding trial, oxidant and antioxidant parameters (MDA, catalase, and glutathione reductase), some innate immunological parameters and immune-related gene expression were measured. Histological examination of liver, spleen, kidney, and intestine was performed. Further, fish groups were challenged against Gram-negative and Gram-positive bacteria;
A. hydrophila
and
L. garvieae
. The results revealed significant improvement (
p
< 0.05) in growth performance and feed utilization in Hilyses-treated groups versus the control group. Blood parameters and liver and kidney functions of Hilyses-supplemented groups were similar to those of the control group. The histological findings of treated groups showed normal tissue structure with multiple focal lymphoid aggregations in the spleen, kidney, and intestine. Both levels of Hilyses successfully enhanced phagocytic activity/index, lysozyme activity, and gene expression of TNF-α, and IL-1β. Fish group fed on 0.4% Hilyses exhibited the highest expression of IL-1β and the least mortality percentages post challenges. Thus, dietary supplementation of Hilyses could promote the growth performance and immunity and increase the resistance of
O. niloticus
against diseases.