Cefuroxime Dilution Error

• Published in: European journal of ophthalmology Vol. 20; no. 2; pp. 460 - 461
• Main Authors: Sakarya, Yasar, Sakarya, Rabia
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-03-2010
• Subjects: Aged; Anterior Chamber; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Cefuroxime - administration & dosage; Cefuroxime - adverse effects; Dose-Response Relationship, Drug; Endophthalmitis - chemically induced; Endophthalmitis - pathology; Female; Follow-Up Studies; Humans; Injections; Male; Medication Errors; Middle Aged; Phacoemulsification - methods; Pharmaceutical Solutions; Surgical Wound Infection - prevention & control; Endophthalmitis; Cefuroxime; Phacoemulsification
• ISSN: 1120-6721; 1724-6016
• DOI: 10.1177/112067211002000232

Purpose.
To present clinical findings of a cluster of cases of inadvertent high-dose intracameral cefuroxime injection after uneventful phacoemulsification cataract surgery.
Methods.
Six eyes of 6 patients (mean age 68.33 years, range 61–75, 4 male, 2 female) were operated on the same day by the same surgeon. At the end of surgery, 3 mg in 0.1 mL cefuroxime (30 mg/mL, Zinnat, GlaxoSmithKline) was erroneously injected into anterior chamber of 6 eyes. Incorrect dilution of cefuroxime was noticed at the end of operation day.
Results.
The 6 patients were followed up very closely every day during the first week. No adverse reaction or inflammation was observed at postoperative examination. All patients achieved 20/20 or better vision at the end of the first week.
Conclusions.
Inadvertent intracameral (3 mg in 0.1 mL) cefuroxime injection did not cause any detectable adverse effect on ocular tissues.