Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

• Published in: Curēus (Palo Alto, CA) Vol. 14; no. 4; p. e23986
• Main Authors: Bhatti, Harneet, Cordova Sanchez, Andres, Dhungana, Rajat, Carvounis, Christos, Singh, Avneet
• Format: Journal Article
• Language: English
• Published: United States Cureus Inc 09-04-2022; Cureus
• Subjects: Age; Cardiac function; Cardiology; Cardiovascular disease; Coronary vessels; Coronaviruses; COVID-19; Diabetes; Ejection fraction; Hospitalization; Hypertension; Internal Medicine; Kidney diseases; Mortality; Peptides; Regression analysis; Severe acute respiratory syndrome coronavirus 2; Software; Vein & artery diseases; United States > US; Chicago Illinois; covid-19; myocardial strain; transthoracic echocardiography; left ventricular function; left ventricular global longitudinal strain
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.23986

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, is an ongoing pandemic that has affected millions globally. Many infected patients have been noted to have cardiovascular damage. Prior to the development of clinical symptoms, the use of transthoracic echocardiography, specifically with measurements of left ventricular global longitudinal strain (LVGLS), may provide an additional prognostic marker for patients infected with COVID-19. We sought to determine whether patients with COVID-19 and reduced LVGLS have an increased risk for mortality. The mean LVGLS was determined to be significantly lower in the non-survivors compared to the survivors (-11.6 ± 1.8 vs -15.4 ± 0.74, p<0.05). It should be noted, however, that even those that survived were found to have reduced LVGLS (<-18.5%). A multivariate logistic regression analysis was also performed that demonstrated a relationship between reduced LVGLS and an increased risk for mortality. Overall, our data indicate that COVID-19 patients may have subclinical left ventricular dysfunction, and that critically ill patients may have a greater decline in cardiac dysfunction.