The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens

• Published in: The Journal of experimental medicine Vol. 175; no. 1; pp. 41 - 47
• Main Authors: Pullen, A M, Choi, Y, Kushnir, E, Kappler, J, Marrack, P
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 01-01-1992
• Subjects: Amino Acid Sequence; Animals; Antigens, Viral - genetics; Base Sequence; Cloning, Molecular; DNA - genetics; DNA - isolation & purification; Genome; Interleukin-2 - biosynthesis; Liver - immunology; Mammary Tumor Virus, Mouse - genetics; Mammary Tumor Virus, Mouse - immunology; Mice; Mice, Inbred Strains; Minor Lymphocyte Stimulatory Antigens - genetics; Minor Lymphocyte Stimulatory Antigens - immunology; Molecular Sequence Data; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Open Reading Frames; Phenotype; Polymerase Chain Reaction; Repetitive Sequences, Nucleic Acid; Sequence Homology, Nucleic Acid; T-Lymphocytes - immunology; Transfection
• ISSN: 0022-1007; 1540-9538
• DOI: 10.1084/jem.175.1.41

Mice expressing the minor lymphocyte stimulation antigens, Mls-1a, -2a, or -3a, singly on the B10.BR background have been generated. Mls phenotypes correlate with the integration of mouse mammary tumor viruses (MTV) in the mouse genome. The open reading frames within the 3' long terminal repeats of the integrated MTVs 1, 3, 6, and 13 encode V beta 3-specific superantigens. Sequence data for these viral superantigens is presented, indicating that it is the COOH-terminal portion of the viral superantigen that interacts with the T cell receptor V beta element.