A new single-stage method for obtaining of betulin phenylcarbamates

A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives - phenyl...

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Bibliographic Details
Published in:	Journal of asian natural products research Vol. 20; no. 12; pp. 1162 - 1166
Main Authors:	Mamaeva, A. Elena, Kaliyeva, S. Saltanat, Bakibaev, A. Abdigali, Tashenov, K. Auezkhan, Nurpeiis, E. Yenglik
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 02-12-2018 Taylor & Francis Ltd
Subjects:	1-phenylurea betulin Molecular Structure O-carbamoylation Pentacyclic triterpenoids phenylcarbamates Phenylcarbamates - chemistry phenylisocyanate Phenylurea Phenylurea Compounds - chemistry Protein Carbamylation Reagents Triterpenes - chemistry O-carbamoylation betulin phenylcarbamates 1-phenylurea Pentacyclic triterpenoids phenylisocyanate
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Summary:	A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives - phenylcarbamates are valuable as bioactive substances.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1028-6020 1477-2213
DOI:	10.1080/10286020.2017.1382480