Exosome-based therapies for mucosal delivery

• Published in: International journal of pharmaceutics Vol. 608; p. 121087
• Main Authors: Peswani Sajnani, Shilpa Lekhraj, Zhang, Yunyue, Vllasaliu, Driton
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25-10-2021
• Subjects: Blood-brain barrier; Drug delivery; Exosomes; Mucosal barriers; Nasal delivery; Mucosal barriers; Drug delivery; Blood-brain barrier; Exosomes; Nasal delivery
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2021.121087

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Exosomes are membrane-bound extracellular nanovesicles secreted by most cells and found in multiple sources, including bodily fluids, plants, fruit, and bovine milk. They play an important role as mediators of intercellular communication, having a distinct ability to carry small molecules, proteins, and nucleic acids to recipient cells over large distances. Moreover, competency in crossing usually poorly permeable biological barriers has led to their promising use in diagnostics and in therapeutics, either as therapeutic entities on their own or as drug delivery vehicles, with superior stability, biocompatibility, circulation time and target specificity in comparison to conventional drug delivery systems. The aim of this review is to summarise and critically discuss the current literature on the use of exosomes in a therapeutic setting, with a particular focus on their use as drug delivery vehicles for mucosal drug delivery.