Comparison of the effects of ketamine-dexmedetomidine and sevoflurane-sufentanil anesthesia on cardiac biomarkers after cardiac surgery: an observational study

• Published in: Physiological research Vol. 61; no. 1; pp. 63 - 72
• Main Authors: Ríha, H, Kotulák, T, Březina, A, Hess, L, Kramář, P, Szárszoi, O, Netuka, I, Pirk, J
• Format: Journal Article
• Language: English
• Published: Czech Republic Institute of Physiology 01-01-2012
• Subjects: Aged; Analgesics; Anesthetics, Combined; Anesthetics, Inhalation; Biomarkers; Biomarkers - blood; Blood; Cardiotonic Agents - pharmacology; Cardiovascular disease; Clinical trials; Dexmedetomidine; Drug dosages; Female; Humans; Ischemia; Ketamine; Kinases; Male; Methyl Ethers; Middle Aged; Mortality; Retrospective Studies; Sevoflurane; Studies; Sufentanil; Surgical apparatus & instruments; Thoracic Surgery
• ISSN: 0862-8408; 1802-9973
• DOI: 10.33549/physiolres.932224

Inhalational anesthetics have demonstrated cardioprotective effects against myocardial ischemia-reperfusion injury. Clinical studies in cardiac surgery have supported these findings, although not with the consistency demonstrated in experimental studies. Recent investigations have questioned the advantages of inhalational over intravenous anesthetics with respect to cardiac protection. Ketamine has been shown to be comparable with sufentanil, and has even demonstrated anti-inflammatory properties. Dexmedetomidine has been established as a sedative/anesthetic drug with analgesic properties, and has also demonstrated myocardial protective effects. In this retrospective observational study, the influence of ketamine-dexmedetomidine-based anesthesia (KET-DEX group; n=17) on the release of cardiac biomarkers was compared with that of sevoflurane-sufentanil-based anesthesia (SEVO group; n=21) in patients undergoing elective coronary artery bypass grafting. Compared with the SEVO group, the KET-DEX group exhibited significantly reduced cardiac troponin I (2.22+/-1.73 vs. 3.63+/-2.37 microg/l; P=0.02) and myocardial fraction of creatine kinase (CK-MB) levels (12.4+/-10.4 vs. 20.3+/-11.2 microg/l; P=0.01) on the morning of the first postoperative day. Furthermore, cardiac troponin I release, evaluated as the area under the curve, was significantly reduced in the KET-DEX group (32.1+/-20.1 vs. 50.6+/-23.2; P=0.01). These results demonstrate the cardioprotective effects of ketamine-dexmedetomidine anesthesia compared with those of sevoflurane-sufentanil anesthesia.