Transporters involved in uptake of di- and tricarboxylates in Bacillus subtilis

• Published in: Antonie van Leeuwenhoek Vol. 84; no. 1; pp. 69 - 80
• Main Authors: KROM, Bastiaan P, WARNER, Jessica B, KONINGS, Wil N, LOLKEMA, Juke S
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01-01-2003; Springer Nature B.V
• Subjects: Anaerobic conditions; Bacillus subtilis - genetics; Bacillus subtilis - metabolism; Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Base Sequence; Biological and medical sciences; Biological Transport; Carrier Proteins - genetics; Carrier Proteins - metabolism; Dicarboxylic Acid Transporters - genetics; Dicarboxylic Acid Transporters - metabolism; Dicarboxylic Acids - metabolism; Energy sources; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Bacterial; Genetics; Metabolism. Enzymes; Microbiology; Molecular Sequence Data; Multigene Family; Sequence Alignment; Tricarboxylic Acids - metabolism; Characterization; Regulation(control); Bacillales; Bacillus subtilis; Bacteria; Bacillaceae; Uptake; Krebs cycle; Carrier protein
• ISSN: 0003-6072; 1572-9699
• DOI: 10.1023/A:1024445131925

Di- and tricarboxylates found as intermediates in the tricarboxylic acid cycle can be utilized by many bacteria and serve as carbon and energy source under aerobic and anaerobic conditions. A prerequisite for metabolism is that the carboxylates are transported into the cells across the cytoplasmic membrane. Bacillus subtilis is able to metabolize many di- and tricarboxylates and in this overview the available data on all known and putative di- and tricarboxylate transporters in B. subtilis is summarized. The B. subtilis transporters, that are of the secondary type, are discussed in the context of the protein families to which they belong. Available data on biochemical characterization, regulation of gene expression and the physiological function is summarized. It is concluded that in B. subtilis multiple transporters are present for tricarboxylic acid cycle intermediates.