Intervertebral disc-on-a-chip: a precision engineered toolbox for low back pain studies

Current in vitro intervertebral disc (IVD) models do not fully recapitulate the complex mechanobiology of native tissue, and so far there is no strategy to effectively evaluate IVD regeneration. The development of a modular microfluidic on-chip model is expected to enhance the physiological relevanc...

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Bibliographic Details
Published in:	Trends in biotechnology (Regular ed.) Vol. 41; no. 11; pp. 1339 - 1342
Main Authors:	Tavakoli, Javad, Diwan, Ashish D., Tipper, Joanne L.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-11-2023 Elsevier Limited
Subjects:	Back pain Biology Biomedical materials Cell culture Collagen Design disc microstructure disc regeneration Engineering research Hypotheses intervertebral disc-on-a-chip Intervertebral discs Laboratory animals Load Low back pain Mechanical properties Microfluidics Physiology Tissue engineering disc regeneration intervertebral disc-on-a-chip microfluidics low back pain disc microstructure
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Summary:	Current in vitro intervertebral disc (IVD) models do not fully recapitulate the complex mechanobiology of native tissue, and so far there is no strategy to effectively evaluate IVD regeneration. The development of a modular microfluidic on-chip model is expected to enhance the physiological relevance of experimental data leading to successful clinical outcomes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0167-7799 1879-3096
DOI:	10.1016/j.tibtech.2023.04.009