Prognostic value of oxygen saturation and heart rate during a six-minute walk test in pediatric pulmonary hypertension

• Published in: Turkish journal of medical sciences Vol. 51; no. 4; pp. 1833 - 1840
• Main Authors: Atasayan, Vildan, Canbeyli, Fatma, Tunaoğlu, Fatma Sedef, Oğuz, Ayşe Deniz, Çelik, Bülent, Kula, Serdar
• Format: Journal Article
• Language: English
• Published: Turkey The Scientific and Technological Research Council of Turkey 30-08-2021
• Subjects: Child; Exercise Test; Female; Heart Rate - physiology; Humans; Hypertension, Pulmonary; Male; Oxygen; Oxygen Saturation - physiology; Prognosis; Retrospective Studies; Walk Test; 6-minute walk test; heart rate; pulmonary arterial hypertension; survival
• ISSN: 1300-0144; 1303-6165
• DOI: 10.3906/sag-2004-220

To evaluate the pre and post-treatment heart rate and oxygen (O2) saturation values measured before, during and after 6MWT in children who received PAH-specific treatment and to determine the effect of these variables on prognosis.
This retrospective study included 29 patients who were diagnosed as PAH and treated. The transcutaneous O2 saturation and heart rate levels were recorded before the test: baseline (Sat0, HR0), at the end of the test: exercise (Sat1, HR1) and 5 min after the test: recovery (Sat2, HR2). The increase in heart rate was defined as HR1-HR0 and the decrease in saturation as Sat0-Sat1. The results obtained before and after the PAH-specific treatment were analyzed and their effect on survival was assessed.
Fifteen of 29 patients were female (51.7%). The mean age was 127.2 ± 44.8 months and the median follow-up time was 60 (12–156) months. Only pre-treatment HR1 was found associated with survival. The mean HR1 value of survivors was 122.8 ± 18.4 and that of deceased 94.3 ± 19.1 (p = 0.03). Post-treatment 6MWT was associated with survival. It was 453.3 ± 96.5 m for survivors and 250 ± 135.2 m for deceased (p = 0.02).
Post-treatment 6MWT, FC and proBNP had prognostic value in pediatric patients with PAH. The decrease in saturation and increase in heart rate were not found to have a prognostic value. Pre-treatment HR1 was associated with survival. Identification of these prognostic factors at the beginning and throughout the treatment may be a guide for detecting the severity of the disease and follow-up.