Appetite suppression and weight loss after the cannabinoid antagonist SR 141716

The effect of the cannabinoid CB 1 receptor antagonist, SR 141716, on food intake and body weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 (2.5 and 10 mg/kg; i.p.) reduced dose-dependently both food intake and body weight. Tolerance to the anorectic effect...

Full description

Saved in:

Bibliographic Details
Published in:	Life sciences (1973) Vol. 63; no. 8; pp. PL113 - PL117
Main Authors:	Colombo, Giancarlo, Agabio, Roberta, Diaz, Giacomo, Lobina, Carla, Reali, Roberta, Gessa, Gian Luigi
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 1998
Subjects:	Animals Appetite - drug effects Appetite Depressants - pharmacology body weight brain cannabinoid receptor Cannabinoids - antagonists & inhibitors Drinking - drug effects Drug Tolerance Eating - drug effects food intake Kinetics Male Piperidines - pharmacology Pyrazoles - pharmacology Rats Rats, Wistar Rimonabant SR 141716 Weight Loss - drug effects body weight brain cannabinoid receptor SR 141716 food intake
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The effect of the cannabinoid CB 1 receptor antagonist, SR 141716, on food intake and body weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 (2.5 and 10 mg/kg; i.p.) reduced dose-dependently both food intake and body weight. Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR 141716-treated rats remained markedly below that of vehicle-treated rats throughout the entire treatment period (14 days). The results suggest that brain cannabinoid receptors are involved in the regulation of appetite and body weight.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0024-3205 1879-0631
DOI:	10.1016/S0024-3205(98)00322-1