NOVEL CYCLOSAL NUCLEOTIDES WITH REDUCED INHIBITORY POTENCY TOWARD HUMAN BUTYRYLCHOLINESTERASE

Two novel cycloSal-d4T monophosphates (d4TMPs) with increased steric demand have been synthesized via a new synthetic route. While 3-cyclohexyl-cycloSal d4TMP did not show a significantly reduced inhibitory potency toward human butyrylcholinesterase, the opposite was the case for the second novel pr...

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Bibliographic Details
Published in:	Nucleosides, nucleotides & nucleic acids Vol. 24; no. 5-7; pp. 519 - 522
Main Authors:	Ducho, C., Jessel, S., Gisch, N., Balzarini, J., Meier, C.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis Group 01-01-2005
Subjects:	Antiviral Activity Antiviral Agents - pharmacology Binding Sites Butyrylcholinesterase Butyrylcholinesterase - chemistry Chemistry, Pharmaceutical - methods Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - pharmacology cycloSal Drug Design Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Humans Hydrogen-Ion Concentration Hydrolysis Models, Chemical Nucleotides - chemistry Nucleotides - pharmacology Pronucleotides Stereoisomerism Temperature
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Summary:	Two novel cycloSal-d4T monophosphates (d4TMPs) with increased steric demand have been synthesized via a new synthetic route. While 3-cyclohexyl-cycloSal d4TMP did not show a significantly reduced inhibitory potency toward human butyrylcholinesterase, the opposite was the case for the second novel pronucleotide, bis-(cycloSal-d4TMP).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1525-7770 1532-2335
DOI:	10.1081/NCN-200061791