A New Predictor of Mortality in ST-Elevation Myocardial Infarction: The Uric Acid Albumin Ratio

• Published in: Angiology Vol. 73; no. 5; pp. 461 - 469
• Main Authors: Kalkan, Sedat, Cagan Efe, Süleyman, Karagöz, Ali, Zeren, Gönül, Yılmaz, Mehmet Fatih, Şimşek, Barış, Batgerel, Ulaankhuu, Özkalaycı, Flora, Tanboğa, İbrahim Halil, Oduncu, Vecih, Karabay, Can Yücel, Kırma, Cevat
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-05-2022
• Subjects: Aged; Albumins; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Proportional Hazards Models; Risk Factors; ST Elevation Myocardial Infarction - diagnosis; ST Elevation Myocardial Infarction - therapy; Uric Acid; mortality; uric acid/albumin ratio; ST-elevation myocardial infarction; uric acid; albumin
• ISSN: 0003-3197; 1940-1574
• DOI: 10.1177/00033197211066362

Several studies have shown that high uric acid (UA) and low serum albumin (SA) values increase the risk of cardiovascular disease and mortality in ST-elevation myocardial infarction (STEMI). We determined whether the uric acid/albumin ratio (UAR) is a predictor of mortality in STEMI patients. All patients who presented at our center with a diagnosis of STEMI and underwent percutaneous intervention from 2015 to 2020 were screened consecutively; 4599 patients were included. A Cox proportional hazards model was used to evaluate UAR, and adjusted predictors obtained from laboratory findings and clinical characteristics contributed to mortality. Also, a regression model was presented with a directed acyclic graph (DAG). The median age of the patients was 58 years (IQR [interquartile range]: 50–67); 3581 patients (77.9%) were male. The incidence of mortality in the entire patient group was 11.9%. Median follow-up duration of all groups was 42 months. Multivariate Cox proportional regression (model-1) analysis showed age (increase 50 to 67 years; HR [hazard ratio]: 1.34, 95% CI 1.18–1.52) and UAR (increase 1.15–1.73; HR: 1.33, 95% CI 1.16–1.52) were associated with mortality. UAR may be a prognostic factor for mortality in STEMI patients and an easily accessible parameter to identify high-risk patients.