A comparison of enalapril 20 mg once daily versus 10 mg twice daily in terms of blood pressure lowering and patient compliance
To compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance. Cross-over study of patients randomly assigned to a sequence of enalapril 20 mg once daily or 10 mg twice daily in three 4-week periods following a 4-week placebo run-in. General...
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| Published in: | Journal of hypertension Vol. 17; no. 11; pp. 1627 - 1631 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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Hagerstown, MD
Lippincott Williams & Wilkins
01-11-1999
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| Abstract | To compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance.
Cross-over study of patients randomly assigned to a sequence of enalapril 20 mg once daily or 10 mg twice daily in three 4-week periods following a 4-week placebo run-in.
General practices in the greater Belfast and Lisburn area in Northern Ireland.
Twenty-five hypertensive patients who had a mean diastolic blood pressure of between 90 and 110 mm Hg after receiving placebo for 4 weeks.
Reduction in blood pressure and estimation of patient compliance.
Patient compliance was superior on the once daily regimen. However, the twice daily regimen was associated with a greater blood pressure reduction which almost reached statistical significance at the 5% level.
Enalapril 20 mg should be prescribed as 10 mg twice daily and measures taken to improve patient compliance. |
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| AbstractList | To compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance.
Cross-over study of patients randomly assigned to a sequence of enalapril 20 mg once daily or 10 mg twice daily in three 4-week periods following a 4-week placebo run-in.
General practices in the greater Belfast and Lisburn area in Northern Ireland.
Twenty-five hypertensive patients who had a mean diastolic blood pressure of between 90 and 110 mm Hg after receiving placebo for 4 weeks.
Reduction in blood pressure and estimation of patient compliance.
Patient compliance was superior on the once daily regimen. However, the twice daily regimen was associated with a greater blood pressure reduction which almost reached statistical significance at the 5% level.
Enalapril 20 mg should be prescribed as 10 mg twice daily and measures taken to improve patient compliance. OBJECTIVETo compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance.DESIGNCross-over study of patients randomly assigned to a sequence of enalapril 20 mg once daily or 10 mg twice daily in three 4-week periods following a 4-week placebo run-in.SETTINGGeneral practices in the greater Belfast and Lisburn area in Northern Ireland.PATIENTSTwenty-five hypertensive patients who had a mean diastolic blood pressure of between 90 and 110 mm Hg after receiving placebo for 4 weeks.MAIN OUTCOME MEASURESReduction in blood pressure and estimation of patient compliance.RESULTSPatient compliance was superior on the once daily regimen. However, the twice daily regimen was associated with a greater blood pressure reduction which almost reached statistical significance at the 5% level.CONCLUSIONSEnalapril 20 mg should be prescribed as 10 mg twice daily and measures taken to improve patient compliance. |
| Author | MCDERMOTT, B. J GIRVIN, B JOHNSTON, G. D |
| Author_xml | – sequence: 1 givenname: B surname: GIRVIN fullname: GIRVIN, B organization: Department of Therapeutics and Pharmacology, The Queen's University of Belfast, Whitla Medical Building, Belfast, United Kingdom – sequence: 2 givenname: B. J surname: MCDERMOTT fullname: MCDERMOTT, B. J organization: Department of Therapeutics and Pharmacology, The Queen's University of Belfast, Whitla Medical Building, Belfast, United Kingdom – sequence: 3 givenname: G. D surname: JOHNSTON fullname: JOHNSTON, G. D organization: Department of Therapeutics and Pharmacology, The Queen's University of Belfast, Whitla Medical Building, Belfast, United Kingdom |
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| Cites_doi | 10.1016/0140-6736(90)90944-Z 10.1038/clpt.1983.198 10.2307/2530762 10.1161/01.HYP.15.3.301 10.1001/archinte.150.9.1881 10.1038/clpt.1982.125 10.1097/00004872-199007000-00004 10.1097/00004872-199012000-00003 10.1007/BF00193697 10.1097/00004872-199412001-00014 10.1111/j.1600-0773.1990.tb00847.x 10.1038/clpt.1983.101 10.1136/hrt.60.3.177 |
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| Keywords | Human Hypertension Enzyme Single dose Enzyme inhibitor Cardiovascular disease Multiple dose Drug compliance Peptidases Chemotherapy Treatment Enalapril Peptidyl-dipeptidase A Hydrolases Peptidyl-dipeptidases Antihypertensive agent Arterial pressure |
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| References | (R12-17-20110409) 1990; 67 Ferguson (R5-17-20110409) 1982; 32 Collins (R16-17-20110409) 1991; 335 Saris (R2-17-20110409) 1983; 31 Detry (R9-17-20110409) 1995; 47 Ebbutt (R13-17-20110409) 1984; 40 Evans (R15-17-20110409) 1988; 60 Eisen (R17-17-20110409) 1990; 150 Chrysant (R6-17-20110409) 1983; 33 Meredith (R7-17-20110409) 1990; 8 Donnelly (R8-17-20110409) 1990; 15 Waeber (R10-17-20110409) 1994; 12 Simon (R3-17-20110409) 1983; 34 McMahon (R4-17-20110409) 1986; 40 OBrien (R14-17-20110409) 1990; 8 |
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| Snippet | To compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance.
Cross-over study of patients randomly... OBJECTIVETo compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance.DESIGNCross-over study of... |
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| SubjectTerms | Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive agents Biological and medical sciences Blood Pressure - drug effects Blood Pressure Monitoring, Ambulatory Cardiovascular system Cross-Over Studies Drug Administration Schedule Enalapril - administration & dosage Enalapril - therapeutic use Humans Hypertension - drug therapy Hypertension - physiopathology Medical sciences Patient Compliance Pharmacology. Drug treatments Posture - physiology |
| Title | A comparison of enalapril 20 mg once daily versus 10 mg twice daily in terms of blood pressure lowering and patient compliance |
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