A comparison of enalapril 20 mg once daily versus 10 mg twice daily in terms of blood pressure lowering and patient compliance

• Published in: Journal of hypertension Vol. 17; no. 11; pp. 1627 - 1631
• Main Authors: GIRVIN, B, MCDERMOTT, B. J, JOHNSTON, G. D
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01-11-1999
• Subjects: Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Antihypertensive agents; Biological and medical sciences; Blood Pressure - drug effects; Blood Pressure Monitoring, Ambulatory; Cardiovascular system; Cross-Over Studies; Drug Administration Schedule; Enalapril - administration & dosage; Enalapril - therapeutic use; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Medical sciences; Patient Compliance; Pharmacology. Drug treatments; Posture - physiology; Human; Hypertension; Enzyme; Single dose; Enzyme inhibitor; Cardiovascular disease; Multiple dose; Drug compliance; Peptidases; Chemotherapy; Treatment; Enalapril; Peptidyl-dipeptidase A; Hydrolases; Peptidyl-dipeptidases; Antihypertensive agent; Arterial pressure
• ISSN: 0263-6352; 1473-5598
• DOI: 10.1097/00004872-199917110-00017

To compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance.
Cross-over study of patients randomly assigned to a sequence of enalapril 20 mg once daily or 10 mg twice daily in three 4-week periods following a 4-week placebo run-in.
General practices in the greater Belfast and Lisburn area in Northern Ireland.
Twenty-five hypertensive patients who had a mean diastolic blood pressure of between 90 and 110 mm Hg after receiving placebo for 4 weeks.
Reduction in blood pressure and estimation of patient compliance.
Patient compliance was superior on the once daily regimen. However, the twice daily regimen was associated with a greater blood pressure reduction which almost reached statistical significance at the 5% level.
Enalapril 20 mg should be prescribed as 10 mg twice daily and measures taken to improve patient compliance.