A Novel and Convenient Method for the Synthesis of Free 5′-Thiol Modified Oligonucleotides

The synthesis of free 5′-thiol-modified oligonucleotides using a 4,4′,4″-trimethoxytrityl (TMTr)-protected linker and standard Poly-Pak TM purification has been described.

Saved in:

Bibliographic Details
Published in:	Nucleosides, nucleotides & nucleic acids Vol. 22; no. 5-8; pp. 1297 - 1299
Main Authors:	Kupihár, Z., Kovács, G., Kele, Z., Darula, Z., Kovács, L.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis Group 01-10-2003
Subjects:	5′-Thiol linker Base Sequence Indicators and Reagents Oligodeoxyribonucleotides - chemical synthesis Oligodeoxyribonucleotides - chemistry Oligonucleotide conjugation Phosphoramidite Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Sulfhydryl Compounds TMTr removal
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The synthesis of free 5′-thiol-modified oligonucleotides using a 4,4′,4″-trimethoxytrityl (TMTr)-protected linker and standard Poly-Pak TM purification has been described.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1525-7770 1532-2335
DOI:	10.1081/NCN-120022950