Chemoenzymatic synthesis of highly enantiomerically enriched secondary alcohols with a thiazolic core

Chemoenzymatic synthesis of highly enantiomerically enriched secondary alcohols with a thiazolic core

Stereoselective preparative enzymatic acylation and hydrolysis/methanolysis of various C-substituted rac-thiazol-2-yl-methanols were achieved for the preparation of enantiopure or enantiomerically enriched, naturally occurring 2-hydroxymethylthiazoles. The absolute configurations of the resulting se...

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Bibliographic Details
Published in:Tetrahedron: asymmetry Vol. 23; no. 6-7; pp. 474 - 481
Main Authors: Pop, Laura, Lassalas, Pierrik, Bencze, László Csaba, Toşa, Monica Ioana, Nagy, Botond, Irimie, Florin Dan, Hoarau, Christophe
Format: Journal Article
Language:English
Published: Elsevier Ltd 15-04-2012
Elsevier
Subjects:
Chemical Sciences
Organic chemistry
Online Access:Get full text
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Summary:Stereoselective preparative enzymatic acylation and hydrolysis/methanolysis of various C-substituted rac-thiazol-2-yl-methanols were achieved for the preparation of enantiopure or enantiomerically enriched, naturally occurring 2-hydroxymethylthiazoles. The absolute configurations of the resulting secondary alcohols were determined by a detailed 1H NMR study of Mosher’s derivatives.
ISSN:0957-4166
1362-511X
0957-4166
DOI:10.1016/j.tetasy.2012.03.014