Changes in renal function with aging

Changes in renal function with aging

Despite losing 20%-25% of their original kidney volume, older individuals maintain body fluid hemostasis under most circumstances; however, their ability to withstand environmental, disease-related, or iatrogenic stresses becomes progressively narrowed. Glomerular filtration rates fall with each dec...

Full description

Saved in:
Bibliographic Details
Published in:Clinics in geriatric medicine Vol. 14; no. 2; p. 199
Main Author: Beck, L H
Format: Journal Article
Language:English
Published: United States 01-05-1998
Subjects:
Adult
Aged
Aging - physiology
Diuresis
Female
Glomerular Filtration Rate - physiology
Humans
Hypernatremia - etiology
Hyponatremia - etiology
Kidney - physiology
Male
Middle Aged
Natriuresis
Water-Electrolyte Balance - physiology
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite losing 20%-25% of their original kidney volume, older individuals maintain body fluid hemostasis under most circumstances; however, their ability to withstand environmental, disease-related, or iatrogenic stresses becomes progressively narrowed. Glomerular filtration rates fall with each decade, accompanied by limitations on sodium conservation, potassium ion secretion, and acid excretion. Medications used by older patients are a common cause of hyperkalemia through a number of pathophysiologic mechanisms. In addition, water homeostasis frequently fails due to defects in thirst, urinary concentrating ability, and free water excretion, resulting in hypernatremia or hyponatremia in many sick older patients.
ISSN:0749-0690
DOI:10.1016/S0749-0690(18)30113-7