Azaindolines: derisking the indoline structural alert

4-Substitued azaindolines, which are isosteres of indolines, are useful synthetic building blocks that reduce the risk of bioactivation induced idiosyncratic toxicity have been prepared. Multigram routes to 2,3-dihydro-1 H-pyrrolo[2,3- c]pyridine-4-triflate 16, 2,3-dihydro-1 H-pyrrolo[2,3- b]pyridin...

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Bibliographic Details
Published in:	Tetrahedron letters Vol. 53; no. 4; pp. 377 - 379
Main Authors:	Piatnitski Chekler, Eugene L., Khan, Taukeer A., Mamidala, Rajanikanth, Anderson, James T., Tangirala, Raghuram S., Verhoest, Patrick R., Gilbert, Adam M.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 25-01-2012
Subjects:	Aniline Azaindoline Biocompatibility Biomedical materials Heterocyclic aromatic compounds Indoline Risk Structure alert Surgical implants Tetrahedrons Toxicity Indoline Structure alert Aniline Azaindoline
Online Access:	Get full text
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Summary:	4-Substitued azaindolines, which are isosteres of indolines, are useful synthetic building blocks that reduce the risk of bioactivation induced idiosyncratic toxicity have been prepared. Multigram routes to 2,3-dihydro-1 H-pyrrolo[2,3- c]pyridine-4-triflate 16, 2,3-dihydro-1 H-pyrrolo[2,3- b]pyridine-4-carbonitrile 20 and 4-chloro-2,3-dihydro-1 H-pyrrolo[2,3- d]pyridazine 30 are outlined.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.11.070