Ornithine and lysine based lipotripeptides: synthesis and comparison of transfection efficiency

Ornithine and lysine based lipotripeptides: synthesis and comparison of transfection efficiency

The derivatives of aliphatic tripeptides containing l-ornithine, l-lysine and diesters of l-glutamic acid were synthesized, the physico- chemical properties of dispersions based on them were examined and the dependence of transfection efficiency on the amphiphile:DNA ratio and the structure of the p...

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Bibliographic Details
Published in:Mendeleev communications Vol. 24; no. 5; pp. 262 - 263
Main Authors: Koloskova, Olesya O., Budanova, Ul’yana A., Sumina, Anastasiya M., Sarychev, Grigorii A., Sebyakin, Yurii L.
Format: Journal Article
Language:English
Published: Elsevier B.V 01-09-2014
Subjects:
Aliphatic compounds
Chemical properties
Derivatives
Diesters
Dispersions
Lysine
Peptides
Synthesis
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Summary:The derivatives of aliphatic tripeptides containing l-ornithine, l-lysine and diesters of l-glutamic acid were synthesized, the physico- chemical properties of dispersions based on them were examined and the dependence of transfection efficiency on the amphiphile:DNA ratio and the structure of the peptides was evaluated.
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ISSN:0959-9436
DOI:10.1016/j.mencom.2014.09.004