An efficient regioselective copper catalyzed multi-component synthesis of 1,3-disubstituted pyrazoles

An efficient regioselective copper catalyzed multi-component synthesis of 1,3-disubstituted pyrazoles

An efficient synthesis of unsymmetrically substituted 1,3-pyrazole derivatives has been developed via three-component coupling reaction involving 3-(dimethylamino)-1-phenylprop-2-en-1-one, hydrazine, and aryl halides in one pot process exhibiting high regioselectivity. The pyrazole synthesis proceed...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters Vol. 55; no. 18; pp. 2986 - 2990
Main Authors: Raghunadh, Akula, Meruva, Suresh Babu, Mekala, Ramamohan, Raghavendra Rao, K., Krishna, Thalishetti, Gangadhara Chary, R., Vaikunta Rao, L., Syam Kumar, U.K.
Format: Journal Article
Language:English
Published: Elsevier Ltd 30-04-2014
Subjects:
Aromatic compounds
Chemical reactions
Cross coupling
Cu catalyst and Ullmann cross-coupling reaction
Derivatives
Hydrazines
Michael addition
Multicomponent reaction
Pyrazole
Pyrazoles
Synthesis (chemistry)
Tetrahedrons
Michael addition
Multicomponent reaction
Cu catalyst and Ullmann cross-coupling reaction
Pyrazoles
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient synthesis of unsymmetrically substituted 1,3-pyrazole derivatives has been developed via three-component coupling reaction involving 3-(dimethylamino)-1-phenylprop-2-en-1-one, hydrazine, and aryl halides in one pot process exhibiting high regioselectivity. The pyrazole synthesis proceeds via a sequential series of reactions such as Michael addition, heterocyclization, dehydration, and Ullmann cross-coupling.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.03.125