Effect of Intra-arterial Insulin on Tissue Cholesterol and Fatty Acids in Alloxan-Diabetic Dogs

Insulin and saline were injected into the right and left femoral arteries respectively of 19 alloxan-diabetes-mellitus dogs for 1 to 28 weeks. A significant increase of artery tissue cholesterol and total fatty acids was found on comparing the insulin-administered right leg with the saline-administe...

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Bibliographic Details
Published in:	Circulation research Vol. 9; no. 1; pp. 39 - 43
Main Authors:	Cruz, Anatolio B, Amatuzio, Donald S, Grande, Francisco, Hay, Lyle J
Format:	Journal Article
Language:	English
Published:	United States American Heart Association, Inc 01-01-1961
Subjects:	Alloxan Animals Cholesterol - metabolism Diabetes Mellitus, Experimental Dogs Fatty Acids - metabolism Insulin - pharmacology Lipid Metabolism Old Medline DIABETES MELLITUS/experimental FATTY ACIDS/metabolism CHOLESTEROL/metabolism INSULIN/pharmacology
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Summary:	Insulin and saline were injected into the right and left femoral arteries respectively of 19 alloxan-diabetes-mellitus dogs for 1 to 28 weeks. A significant increase of artery tissue cholesterol and total fatty acids was found on comparing the insulin-administered right leg with the saline-administered left leg. Similarly, a significant increase of total fatty acids in muscle was found on comparing the right with the left leg of the alloxan-diabetes mellitus dogs. No significant differences were observed in the normal animals when the insulin-injected side was compared with the noninjected.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.9.1.39