A rapid, mild, and efficient method for C-5 iodination/thiocyanation of 2-aminothiazoles

An efficient, green, rapid multitasking protocol for the selective C-5 substitution of 2-aminothiazole using iodic acid and aqueous PEG-400 was developed. The method found suitable for C-5 substitution i.e. iodination and thiocyanation of 2-amino thiazole using iodine and ammonium thiocyanate respec...

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Bibliographic Details
Published in:	Phosphorus, sulfur, and silicon and the related elements Vol. 191; no. 8; pp. 1155 - 1159
Main Authors:	Hebade, Madhav J., Kamble, Rahul D., Hese, Shrikant V., Mogle, Pratima P., Ambhore, Ajay N., Kadam, Shuddhodan N., Dawane, Bhaskar S.
Format:	Journal Article
Language:	English
Published:	Abingdon Taylor & Francis 02-08-2016 Taylor & Francis Ltd
Subjects:	2-aminothiazole Aq. PEG-400 iodic acid iodination thiocyanation
Online Access:	Get full text
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Summary:	An efficient, green, rapid multitasking protocol for the selective C-5 substitution of 2-aminothiazole using iodic acid and aqueous PEG-400 was developed. The method found suitable for C-5 substitution i.e. iodination and thiocyanation of 2-amino thiazole using iodine and ammonium thiocyanate respectively. Iodic acid was found to be a good oxidant and aqueous PEG-400 as green reaction solvent.
ISSN:	1042-6507 1563-5325
DOI:	10.1080/10426507.2016.1149851