Multi-level network modeling of cortical dynamics built on the GENESIS environment

• Published in: Neurocomputing (Amsterdam) Vol. 44; pp. 863 - 868
• Main Authors: -Johnsen, J.D, Nielsen, P, Luhmann, H.J, Northoff, G, Kötter, R
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 2002
• Subjects: Brain models; Cells; Computer simulation; Computer simulation packages; Integrative modeling; Visual system; Visual system; Integrative modeling; Computer simulation packages
• ISSN: 0925-2312; 1872-8286
• DOI: 10.1016/S0925-2312(02)00484-8

Detailed network modeling integrating knowledge from different biological levels of description is important for understanding brain function. To facilitate modeling based on collated experimental connectivity data, we implemented tools in the GENESIS simulation environment for automatic generation, visualization and modification of network models with units representing cells, layers or cortical areas. As a further integrative step, representations from different modeling approaches, multicompartmental cells and integrate-and-fire units, could be interfaced in the same model. Development of standardized model description languages would facilitate future integrative efforts, allowing easy combination of desired models and tools from different simulators in one modeling study.