Synthesis of 4′-C-Ethynyl and 4′-C-Cyano Purine Nucleosides from Natural Nucleosides and Their Anti-HIV Activity

Purine 2′-deoxynucleosides bearing an ethynyl or a cyano group at C-4′ of the sugar moiety were synthesized from the corresponding 2′-deoxynucleosides. These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains.

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Bibliographic Details
Published in:	Nucleosides, nucleotides & nucleic acids Vol. 22; no. 5-8; pp. 887 - 889
Main Authors:	Kohgo, Satoru, Yamada, Kohei, Kitano, Kenji, Sakata, Shinji, Hayakawa, Hiroyuki, Nameki, Daisuke, Kodama, Eiichi, Matsuoka, Masao, Mitsuya, Hiroaki, Ohrui, Hiroshi
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis Group 01-10-2003
Subjects:	4′-C-Substituted nucleosides Anti-HIV activitiy Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Deoxyribonucleosides - chemical synthesis Deoxyribonucleosides - chemistry Deoxyribonucleosides - pharmacology Drug Resistance, Viral Drug-resistant HIV Guanine - analogs & derivatives Guanine - chemical synthesis Guanine - pharmacology HIV - classification HIV - drug effects Microbial Sensitivity Tests Purine Nucleosides - chemical synthesis Purine Nucleosides - chemistry Purine Nucleosides - pharmacology
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Summary:	Purine 2′-deoxynucleosides bearing an ethynyl or a cyano group at C-4′ of the sugar moiety were synthesized from the corresponding 2′-deoxynucleosides. These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1525-7770 1532-2335
DOI:	10.1081/NCN-120022678