Chemistry of antipyrine

This review is a literature survey of antipyrine, considered as one of the most valuable compounds in the fields of organic and medicinal chemistry. The biological importance, synthetic procedures, and reactions are discussed. Generally, the preparation of antipyrine was reported through the methyla...

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Bibliographic Details
Published in:	Synthetic communications Vol. 46; no. 19; pp. 1567 - 1594
Main Authors:	Elattar, Khaled M., Fadda, Ahmed A.
Format:	Journal Article
Language:	English
Published:	Philadelphia Taylor & Francis 01-10-2016 Taylor & Francis Ltd
Subjects:	Antipyrine reactions synthesis synthetic and biological importance
Online Access:	Get full text
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Summary:	This review is a literature survey of antipyrine, considered as one of the most valuable compounds in the fields of organic and medicinal chemistry. The biological importance, synthetic procedures, and reactions are discussed. Generally, the preparation of antipyrine was reported through the methylation of the corresponding 1H-pyrazolone following different reaction conditions. The reactions, in general, are electrophilic substitutions at C 4 -position of pyrazolone. The mechanistic pathways of the reactions are surveyed.
ISSN:	0039-7911 1532-2432
DOI:	10.1080/00397911.2016.1211703