Risk factors for ocular complications in adult patients with uveitis

• Published in: European journal of ophthalmology Vol. 30; no. 6; pp. 1381 - 1389
• Main Authors: Prieto-del-Cura, Mar, González-Guijarro, Juan Jacobo
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-11-2020
• Subjects: Adolescent; Adult; Cataract - etiology; Female; Follow-Up Studies; Humans; Infant; Macular Edema - etiology; Male; Middle Aged; Retrospective Studies; Risk Factors; Uveitis - complications; Visual Acuity; Young Adult; cataract; complications; retrospective cohort; iris alterations; macular edema; uveitis; Adult patients
• ISSN: 1120-6721; 1724-6016
• DOI: 10.1177/1120672119899379

Purpose:
To report risk factors for ocular complications in adults with uveitis.
Methods:
Retrospective cohort study of 653 patients with uveitis (869 eyes) followed up for at least 1 month attended between May 1989 and December 2012.
Results:
After a median follow-up of 16 months (interquartile range = 3–59), 43.5% of patients developed one or more complications, including cataract formation (25%), iris alterations (20%), and macular edema (16%) as the most frequent. Older age, intermediate uveitis, chronic course, and uveitis activity >3 months were significantly more frequent among patients with complications. In the multivariate analysis, age ⩾65 years (hazard ratio = 2.76, 95% confidence interval = 1.72–4.4), chronic course (hazard ratio = 1.78, 95% confidence interval = 1.23–259), and uveitis activity >3 months (hazard ratio = 1.94, 95% confidence interval = 1.33–2.84) were predictors of complications.
Conclusion:
In the present series of patients with uveitis, advanced age, chronic uveitis, and inflammatory activity >12 weeks were risk factors for complications.