Malakoplakia With Digestive Tract Involvement in a Pig

• Published in: Veterinary pathology Vol. 51; no. 4; pp. 809 - 811
• Main Authors: Gelmetti, D., Gibelli, L., Gelmini, L., Sironi, G.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-07-2014
• Subjects: Animals; Fatal Outcome; Gastrointestinal Tract - pathology; Immunohistochemistry - veterinary; Inclusion Bodies - pathology; Italy; Lymph Nodes - pathology; Malacoplakia - pathology; Malacoplakia - veterinary; Microscopy, Electron - veterinary; Swine; Swine Diseases - pathology; Italy; gastrointestinal; swine; Michaelis-Gutmann bodies; PRRS; PCV2; stomach; malakoplakia
• ISSN: 0300-9858; 1544-2217
• DOI: 10.1177/0300985813503566

Malakoplakia is a rare, granulomatous, inflammatory disease that mimics malignant tumors and can affect any organ. Herein is described a case of malakoplakia in a 10-month-old slaughter pig. Diffuse, pleomorphic, round cell infiltrates, mainly histiocytes, with a tumor-like growth pattern at gross examination, infiltrated the stomach, pancreas, omentum, and mesenteric lymph nodes. The histiocytes and multinucleated giant cells had concentric, target-like inclusions known as Michaelis-Gutmann bodies. Microorganisms were not detected by the periodic acid–Schiff reaction, Ziehl-Neelsen, Gram, and Warthin-Starry staining or by electron microscopic and bacteriologic investigations. Porcine circovirus type 2 and porcine reproductive and respiratory syndrome viruses were not detected by immunohistochemistry in the sections examined.