The nuclear factor E2-related factor 2 and age-related macular degeneration

• Published in: Arquivos brasileiros de oftalmologia Vol. 86; no. 2; pp. 178 - 187
• Main Authors: Torres, Rogil José de Almeida, Torres, Rogério João de Almeida, Luchini, Andréa, Ferreira, Ana Lúcia Dos Anjos
• Format: Journal Article
• Language: English
• Published: Brazil Conselho Brasileiro de Oftalmologia 01-03-2023
• Subjects: Angiogenesis Inhibitors - therapeutic use; Humans; Intravitreal Injections; NF-E2-Related Factor 2 - therapeutic use; OPHTHALMOLOGY; Ranibizumab - therapeutic use; Vision, Ocular; Wet Macular Degeneration - drug therapy; Oxidação; Macular degeneration; Elemento de resposta antioxidante; Enzyme activator; Fator nuclear eritroide 2 relacionado ao fator 2; Ativador de enzima; NF-E2-Related Factor 2; Oxidation; Antioxidant response element; Degeneração macular
• ISSN: 0004-2749; 1678-2925; 1678-2925
• DOI: 10.5935/0004-2749.20230024

After the discovery of anti-vascular endothelial growth factor agents as treatment of wet age-related macular degeneration, the number of studies with the objective to understand the molecular mechanisms involved in the age-re lated macular degeneration genesis has increased. The importance of the nuclear factor e2-related factor 2 lies in its activation-derived proteins being involved in the maintenance of the redox balance and consequent prevention of degenerative macular disease. This article aims to present the characteristics of nuclear factor e2-related factor 2 and describe the main nuclear factor e2-related factor 2-activated antioxidant enzymes that contribute to the preservation of vision.