Ru-W modified graphitic carbon nitride by a monomer complexation synthesis approach from a tailored polyoxometalate: towards electrochemical detection of hydrogen peroxide released by cells

• Published in: Analytical methods Vol. 15; no. 5; p. 587
• Main Authors: Shabana, Neermunda, Arjun, Ajith Mohan, Rajendran, K, Pathan, Soyeb, Rasheed, P Abdul
• Format: Journal Article
• Language: English
• Published: England 02-02-2023
• Subjects: Dopamine; Graphite - chemistry; Hydrogen Peroxide - chemistry
• ISSN: 1759-9679
• DOI: 10.1039/d2ay01763f

Detection of hydrogen peroxide (H
O
) from cell cultures is important for monitoring different diseases. Here, g-C
N
(gCN) was incorporated into well-defined clusters of RuW (RuW-gCN) through monomer complexation of Ru-substituted phosphotungstate and melamine for electrochemical detection of H
O
. RuW-gCN exhibited enhanced electrochemical sensing properties in comparison to its constituents due to the synergic effects between RuW and gCN. The characterization of RuW-gCN revealed successful complexation to form the composite in addition to the presence of a layered structure of gCN. The electrochemical sensor made of RuW-gCN was able to detect H
O
with a detection limit of 46 nM in the linear ranges from 100 nM to 50 μM and from 50 μM to 1 mM. The developed sensor was employed for the selective detection of H
O
in the presence of analytes like ascorbic acid (AA), dopamine, and glucose in addition to being stable even after a week of storage at room temperature. It has also been verified for real sample application by detecting H
O
produced by cancer cells as a result of an AA trigger.