Sepsis research: Heterogeneity as a foundation rather than an afterthought

Our understanding of sepsis has been hampered by the implicit assumption that sepsis is a homogeneous disease. In this issue of Cell Genomics, Burnham et al.1 have started to characterize the genetic variants and regulatory networks that underlie variations in the individual response to sepsis; this...

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Published in:Cell genomics Vol. 4; no. 7; p. 100608
Main Author: Ciesielski, Timothy H.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 10-07-2024
Elsevier
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Summary:Our understanding of sepsis has been hampered by the implicit assumption that sepsis is a homogeneous disease. In this issue of Cell Genomics, Burnham et al.1 have started to characterize the genetic variants and regulatory networks that underlie variations in the individual response to sepsis; this may eventually enable targeted intervention development. Our understanding of sepsis has been hampered by the implicit assumption that sepsis is a homogeneous disease. In this issue of Cell Genomics, Burnham et al. have started to characterize the genetic variants and regulatory networks that underlie variations in the individual response to sepsis; this may eventually enable targeted intervention development.
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ISSN:2666-979X
2666-979X
DOI:10.1016/j.xgen.2024.100608