Association of C-Reactive Protein-to-Albumin Ratio With the Presence and Progression of Abdominal Aortic Aneurysm

• Published in: Angiology Vol. 72; no. 2; pp. 153 - 158
• Main Authors: Cerşit, Sinan, Öcal, Lutfi, Keskin, Muhammed, Gürsoy, Mustafa Ozan, Kalçik, Macit, Bayam, Emrah, Karaduman, Ahmet, Uysal, Samet, Uslu, Abdulkadir, Küp, Ayhan, Dereli, Seçkin, Arslantaş, Uğur, Türkmen, Mehmet Muhsin
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-02-2021
• Subjects: Aged; Aorta, Abdominal - metabolism; Aortic Aneurysm, Abdominal - diagnosis; Aortic Aneurysm, Abdominal - metabolism; Biomarkers - blood; C-Reactive Protein - metabolism; Case-Control Studies; Computed Tomography Angiography - methods; Cross-Sectional Studies; Disease Progression; Female; Genetic Predisposition to Disease - genetics; Humans; Male; Middle Aged; Risk Factors; C-reactive protein-to-albumin ratio; inflammation; abdominal aortic aneurysm
• ISSN: 0003-3197; 1940-1574
• DOI: 10.1177/0003319720954084

Aortic dilatation due to inflammation may lead to an increase in C-reactive protein (CRP) levels. We investigated the possible relationship between CRP-to-albumin ratio (CAR) and presence and progression of abdominal aortic aneurysms (AAAs). The study included 150 patients previously diagnosed with AAA (diameter 40-54 mm) and 100 normal controls. Clinical and laboratory parameters and maximal cross-sectional AAA diameters (measured by computed tomography angiography) were obtained from all participants at baseline assessment as well as after 1 year for those with an AAA. The patients with AAA had significantly higher serum CAR compared with controls at baseline (P < .001). Increased serum CAR was found to be an independent predictor of the presence of AAA (odds ratio: 3.162, 95% CI: 1.690-5.126, P = .001) after multivariate logistic regression analysis. There was a significant increase in aortic diameter and CAR after 1 year in the patients with AAA (P < .001; P = .003); a significant correlation was found between changes in the diameter of AAAs and CAR (r = 0.414; P = .005). Serum CAR may be useful as an inflammatory biomarker for the presence and progression of AAA.