Delivery of cell membrane impermeable peptides into living cells by using head-to-tail cyclized mitochondria-penetrating peptides

A series of cyclic Arg-rich mitochondria-penetrating peptides were prepared with variation in the macrocycle size and the chirality of Arg residues. A cyclic heptapeptide was demonstrated to be an efficient mitochondria-specific delivery vector for delivering membrane impermeable peptides.

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Bibliographic Details
Published in:	Organic & biomolecular chemistry Vol. 17; no. 45; p. 9693
Main Authors:	Yang, Qian-Qian, Zhu, Liang-Jing, Xi, Tong-Kuai, Zhu, Han-Ying, Chen, Xiao-Xu, Wu, Meng, Sun, Chuan, Xu, Changzhi, Fang, Ge-Min, Meng, Xiangming
Format:	Journal Article
Language:	English
Published:	England 07-12-2019
Subjects:	Cell Membrane - chemistry Cell Membrane - metabolism Cell Survival Cell-Penetrating Peptides - chemistry Cell-Penetrating Peptides - metabolism Cyclization HeLa Cells Humans Mitochondria - chemistry Mitochondria - metabolism Molecular Conformation
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Description
Summary:	A series of cyclic Arg-rich mitochondria-penetrating peptides were prepared with variation in the macrocycle size and the chirality of Arg residues. A cyclic heptapeptide was demonstrated to be an efficient mitochondria-specific delivery vector for delivering membrane impermeable peptides.
ISSN:	1477-0539
DOI:	10.1039/c9ob02075f