Phytochemical analysis of aerial part of Ikonnikovia kaufmanniana and their protection of DNA damage

is an endemic plant of Kazakhstan of which phytochemical analysis has not been reported. The present study found out that this species enriched with antioxidant chemicals. Isolation and structural identification processes reveal twelve phenolic compounds ( - ) having dihydroflavanonol, flavonol, iso...

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Bibliographic Details
Published in:	Natural product research Vol. 35; no. 5; pp. 880 - 883
Main Authors:	Baiseitova, Aizhamal, Jenis, Janar, Kim, Jeong Yoon, Li, Zuo Peng, Park, Ki Hun
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis Ltd 01-03-2021
Subjects:	Annotations Antioxidants Antioxidants - chemistry Damage prevention Deoxyribonucleic acid DNA DNA Damage Endemic plants Flavanols Flavonols Flavonols - analysis Free radicals Hydroxyl radicals Isoflavones Phenolic compounds Phenols Phytochemicals Phytochemicals - analysis Phytochemicals - chemistry Phytochemicals - isolation & purification Plant Components, Aerial - chemistry Plant Extracts - chemistry Plasmids Plasmids - genetics Plumbaginaceae - chemistry Polyphenols - analysis Tandem Mass Spectrometry Ikonnikovia kaufmanniana phytochemical composition DNA damage protection antioxidant activity
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Summary:	is an endemic plant of Kazakhstan of which phytochemical analysis has not been reported. The present study found out that this species enriched with antioxidant chemicals. Isolation and structural identification processes reveal twelve phenolic compounds ( - ) having dihydroflavanonol, flavonol, isoflavone and flavanol skeletons. The annotation of individual components in the extract was carried out by LC-ESI-MS/MS to represent a chemotaxonomic marker of the target plant. The antioxidant activities of all compounds were screened using three different radical sources (DPPH, ORAC, and hydroxyl radicals). Most compounds ( - ) had significant antioxidant activity against three radical sources, and their efficacies were found to differ by their functionality and skeleton. The potential of the isolated compounds in preventing oxidative damage of DNA was evaluated with pBR322 plasmid DNA. Compounds ( , , , and ) had protective effects on DNA damaged with 80% efficacy at 60 μM concentration.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1478-6419 1478-6427
DOI:	10.1080/14786419.2019.1607858