Total synthesis and structural reassignment of garcinielliptone FC, a polycyclic polyprenylated acylphloroglucinol with diverse bioactivity

Total synthesis and structural reassignment of garcinielliptone FC, a polycyclic polyprenylated acylphloroglucinol with diverse bioactivity

Garcinielliptone FC (GFC) was assigned to be a type A polycyclic polyprenylated acylphloroglucinol (PPAP) and was found to exhibit diverse biological activities. Now we revise the structure of GFC to xanthochymol, a type B PPAP, NMR and total synthesis methods. The total syntheses of (±)-xanthochymo...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) Vol. 59; no. 41; p. 6215
Main Authors: Luo, Yang, Grossman, Robert B, Nie, Xiao-Bin, Yang, Xing-Wei
Format: Journal Article
Language:English
Published: England 18-05-2023
Subjects:
Molecular Structure
Phloroglucinol - chemistry
Polycyclic Compounds - chemistry
Triterpenes
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Summary:Garcinielliptone FC (GFC) was assigned to be a type A polycyclic polyprenylated acylphloroglucinol (PPAP) and was found to exhibit diverse biological activities. Now we revise the structure of GFC to xanthochymol, a type B PPAP, NMR and total synthesis methods. The total syntheses of (±)-xanthochymol and (±)-cycloxanthochymol were accomplished in 12 and 13 steps, respectively.
ISSN:1364-548X
DOI:10.1039/d3cc01268a