Coomassie brilliant blue G-250 acts as a potential chemical chaperone to stabilize therapeutic insulin

Our studies show Coomassie Brilliant Blue G-250 as a promising chemical chaperone that stabilises the α-helical native human insulin conformers, disrupting their aggregation. Furthermore, it also increases the insulin secretion. This multipolar effect coupled with its non-toxic nature could be usefu...

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 59; no. 52; p. 8095
Main Authors:	Pariary, Ranit, Dolui, Sandip, Shome, Gourav, Mohid, Sk Abdul, Saha, Achintya, Ratha, Bhisma N, Harikishore, Amaravadhi, Jana, Kuladip, Mandal, Atin K, Bhunia, Anirban, Maiti, Nakul C
Format:	Journal Article
Language:	English
Published:	England 27-06-2023
Subjects:	Humans Insulins Molecular Chaperones Rosaniline Dyes
Online Access:	Get more information
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Summary:	Our studies show Coomassie Brilliant Blue G-250 as a promising chemical chaperone that stabilises the α-helical native human insulin conformers, disrupting their aggregation. Furthermore, it also increases the insulin secretion. This multipolar effect coupled with its non-toxic nature could be useful for developing highly bioactive, targeted and biostable therapeutic insulin.
ISSN:	1364-548X
DOI:	10.1039/d3cc01791e