Cytogenetic surveillance of persons occupationally exposed to genotoxic chemicals

• Published in: Archives of environmental & occupational health Vol. 73; no. 5; pp. 313 - 321
• Main Authors: Pajic, Jelena, Jovicic, Dubravka, Milovanovic, Aleksandar P S
• Format: Journal Article
• Language: English
• Published: United States Kirkpatrick Jordon Foundation 01-01-2018
• Subjects: Adult; Age Factors; Agrochemicals; Biomarkers - analysis; Case-Control Studies; Chemical agents; Chromosome aberrations; Chromosome Aberrations - statistics & numerical data; Cytogenetics; Damage assessment; DNA Damage; Exposure; Female; Genotoxic chemicals; Genotoxicity; Humans; Incidence; Logistic Models; Male; Medical screening; Micronuclei; Middle Aged; Mutagens - adverse effects; Occupational exposure; Occupational Exposure - adverse effects; Occupations; Organic chemistry; Parameters; Pesticides; Population Surveillance; Regression analysis; Serbia - epidemiology; Sex Factors; Smoking; Time Factors; Serbia; genotoxic chemicals; micronuclei; Chromosomal aberrations; premature centromere division
• ISSN: 1933-8244; 2154-4700
• DOI: 10.1080/19338244.2017.1359144

Human genotoxic exposures can occur environmentally, occupationally, or medicinally. The aim of this study was to assess cytogenetic damage (chromosomal aberrations and micronuclei) in persons exposed to chemical agents in medical, agricultural, and industrial occupations. The results showed influences of age, gender, occurrence, and duration of exposure on the extent of cytogenetic damage, but no influence of smoking. Persons exposed to pesticides were allocated significantly higher values of most examined parameters. Among all tested parameters, logistic regression analysis marked tMN, CB, and iCB as the best predictors with high discrimination accuracy of separation between exposed and unexposed persons. The obtained data encourage us to consider certain cytogenetic parameters as valuable markers for preventive medical screening as the extent of cytogenetic damage reflects cumulative exposure events and possible health consequences related to chronic occupational genotoxic exposure.