Structure-Function Studies on the Inhibition of Binding of α-Thrombin to Platelet GpIbα by the Peptide D-Y-Y-P-E and the Artifactual Inhibitory Activity of C-Terminal E in this Peptide

• Published in: Thrombosis research Vol. 88; no. 3; pp. 333 - 335
• Main Authors: Krutzsch, Henry, Williams, Sybil B., McKeown, Laurie P., Gralnick, Harvey R.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 01-11-1997; Elsevier Science
• Subjects: Amino Acid Sequence; Binding Sites; Biological and medical sciences; Blood coagulation. Blood cells; Blood Platelets - drug effects; Blood Platelets - metabolism; Fundamental and applied biological sciences. Psychology; Humans; Molecular and cellular biology; Molecular Sequence Data; Peptides; Peptides - chemistry; Peptides - pharmacology; Platelet; Platelet Glycoprotein GPIb-IX Complex - metabolism; Platelets; Protein Binding - drug effects; Structure-Activity Relationship; Thrombin - metabolism; α-Thrombin; α-Thrombin; Peptides; T, Thr; A, Ala; G; GpIbα, glycoprotein Ib alpha; E, Glu; L, Leu; Gly; P, Pro; PRP, Platelet Rich Plasma; Y, Tyr; Platelets; Human; Serine endopeptidases; Enzyme; Overlapping sequence; Thrombin; Structure function relationship; Peptidases; Platelet; Integrin; Binding capacity; Peptide fragment; Hydrolases; Glycoprotein Ibα; Inhibition
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/S0049-3848(97)00260-0