Synthesis and antimicrobial activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones

Synthesis and antimicrobial activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones

In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activity of various 3-(1,3,4-oxadiazol-2-yl)-quinazolin-4(3H)-ones. The antimicrobial activity of title compounds were examined against two gram positive bacteria (S. aureus, S. pyogene...

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Bibliographic Details
Published in:Scientia pharmaceutica Vol. 78; no. 2; pp. 171 - 193
Main Authors: Patel, Navin B, Patel, Jaymin C
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-04-2010
Österreichische Apotheker-Verlagsgesellschaft
Subjects:
Original Papers
Quinazolin-4(3H)-one
1,3,4-Oxadiazole
Antimicrobial activity
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Summary:In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activity of various 3-(1,3,4-oxadiazol-2-yl)-quinazolin-4(3H)-ones. The antimicrobial activity of title compounds were examined against two gram positive bacteria (S. aureus, S. pyogenes), two gram negative bacteria (E. coli, P. aeruginosa) and three fungi (C. albicans, A. niger, A. clavatus) using the broth microdilution method. Some derivatives bearing a bromo or iodo group exhibited very good antimicrobial activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0036-8709
2218-0532
DOI:10.3797/scipharm.0912-16