An efficient laboratory synthesis of α-deuteriated profens

An efficient and practical laboratory synthesis of a series of 2‐deuterio‐2‐arylpropionic acids (α‐deuterioprofens) is described. The levels of deuterium incorporation are high and the products are synthetically useful. Copyright © 2006 John Wiley & Sons, Ltd.

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Bibliographic Details
Published in:	Journal of labelled compounds & radiopharmaceuticals Vol. 49; no. 10; pp. 903 - 914
Main Authors:	Coumbarides, Gregory S., Dingjan, Marco, Eames, Jason, Flinn, Anthony, Northen, Julian
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-09-2006 Wiley
Subjects:	2-phenyl-propionic acid and profens Biological and medical sciences carboxylic acids Contrast media. Radiopharmaceuticals deuterium Medical sciences Pharmacology. Drug treatments Non steroidal antiinflammatory agent Deuterium 2-phenyl-propionic acid and profens Carboxylic acid Isotope exchange carboxylic acids Arylpropionic acid derivatives Hydrogen Isotopes Chemical synthesis Labelled compound
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Summary:	An efficient and practical laboratory synthesis of a series of 2‐deuterio‐2‐arylpropionic acids (α‐deuterioprofens) is described. The levels of deuterium incorporation are high and the products are synthetically useful. Copyright © 2006 John Wiley & Sons, Ltd.
Bibliography:	ark:/67375/WNG-4PSMLP00-Q ArticleID:JLCR1105 istex:C4F388B6D77439343DE2712FB2BF6B23B3EFA629
ISSN:	0362-4803 1099-1344
DOI:	10.1002/jlcr.1105