Crystallisation of α-lactose monohydrate from dimethyl sulfoxide (DMSO) solutions: influence of β-lactose

• Published in: Journal of crystal growth Vol. 205; no. 3; pp. 368 - 374
• Main Authors: Dincer, T.D., Parkinson, G.M., Rohl, A.L., Ogden, M.I.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 1999; Elsevier
• Subjects: Atomic force microscopy; Cross-disciplinary physics: materials science; rheology; Exact sciences and technology; Lactose; Materials science; Methods of crystal growth; physics of crystal growth; Molecular modelling; Morphology; Physics; Theory and models of crystal growth; physics of crystal growth, crystal morphology and orientation; Atomic force microscopy; Lactose; Molecular modelling; Morphology; DMSO; Organic solvents; Experimental study; Alpha form; Mutarotation; Beta form; Aqueous solutions; Glycosides; Crystal growth from solutions; Crystal morphology; Organic compounds; Hydrates
• ISSN: 0022-0248; 1873-5002
• DOI: 10.1016/S0022-0248(99)00238-9

In this study, the dimethyl sulfoxide (DMSO)–lactose system has been used to study the effect of
β-lactose on the morphology of
α-lactose monohydrate crystals. DMSO was used as the solvent as it greatly reduces the rate of mutarotation of
α-lactose to
β-lactose. It is shown that as the
β-content of the solution increases, the crystal shape starts increasing in the
a
and
b
directions, whereas the major growth occurs in the
c
direction at low levels of
β-lactose. The morphology of the
α-lactose monohydrate crystal calculated by molecular modelling is in good agreement with that of the crystals grown in the presence of low
β-lactose concentrations. Atomic force microscopy has revealed growth spirals and unit cell high steps on the (0
2
0) face of crystals grown in the presence of low
β-anomer concentration.