Unusual malabsorption of levothyroxine

We report a 50-year-old woman, with overt hypothyroidism undergoing thyrotropin (TSH)-stimulating hormone suppressive levothyroxine (LT4) treatment after subtotal thyroidectomy. At her first visit to our department, the laboratory results revealed a borderline low free thyroxine (FT4) level accompan...

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Bibliographic Details
Published in:	Thyroid (New York, N.Y.) Vol. 10; no. 1; p. 93
Main Authors:	Jauk, B, Mikosch, P, Gallowitsch, H J, Kresnik, E, Molnar, M, Gomez, I, Lind, P
Format:	Journal Article
Language:	English
Published:	United States 01-01-2000
Subjects:	Administration, Oral Carcinoma, Papillary - complications Female Humans Hypothyroidism - drug therapy Hypothyroidism - surgery Infusions, Parenteral Malabsorption Syndromes - complications Middle Aged Thyroid Gland - physiopathology Thyroid Neoplasms - complications Thyroidectomy Thyrotropin - blood Thyroxine - blood Thyroxine - pharmacokinetics Triiodothyronine - blood
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Summary:	We report a 50-year-old woman, with overt hypothyroidism undergoing thyrotropin (TSH)-stimulating hormone suppressive levothyroxine (LT4) treatment after subtotal thyroidectomy. At her first visit to our department, the laboratory results revealed a borderline low free thyroxine (FT4) level accompanied by a clearly elevated TSH level. Both parameters did not significantly change during therapy with an oral dose of 500 microg of LT4. Investigations revealed malabsorption of oral administrated LT4. Thyroid serum hormone levels only became normal during parenteral therapy with LT4.
ISSN:	1050-7256
DOI:	10.1089/thy.2000.10.93