A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response

Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research has, however, revealed that leptin's biological action is not restricted to its effects on appetite and food intake, but rather has a much more pleiotro...

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Bibliographic Details
Published in:	Current drug targets. Inflammation & allergy Vol. 1; no. 3; p. 277
Main Authors:	Waelput, W, Brouckaert, P, Broekaert, D, Tavernier, J
Format:	Journal Article
Language:	English
Published:	Netherlands 01-09-2002
Subjects:	Adaptation, Physiological Animals Humans Immunity - physiology Immunity, Cellular - physiology Inflammation - physiopathology Leptin - physiology Metallothionein - biosynthesis Neuropeptide Y - biosynthesis Starvation - physiopathology Systemic Inflammatory Response Syndrome - physiopathology T-Lymphocytes - immunology
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Summary:	Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research has, however, revealed that leptin's biological action is not restricted to its effects on appetite and food intake, but rather has a much more pleiotropic character. Evidence is now accumulating that it has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review, we have focused on the effects of leptin in the immune system, which can be found in both the antigen-specific immunity and in the inflammatory effector system.
ISSN:	1568-010X
DOI:	10.2174/1568010023344634