The Influence of Type And Duration of Cardiovascular Complications On Antioxidative Parameter Values In Type 2 Diabetic Patients

• Published in: Journal of medical biochemistry Vol. 26; no. 1; pp. 10 - 16
• Main Authors: colak, Emina, Dimitrijevic-Sreckovic, Vesna, Dordevic, Predrag, Stankovic, Sanja, Majkic-Singh, Nada, Lalic, Katarina, Lalic, Nebojsa
• Format: Journal Article
• Language: English
• Published: Belgrade Versita 01-01-2007; Society of Medical Biochemists of Serbia; Society of Medical Biochemists of Serbia, Belgrade
• Subjects: antioksidantna zaštita; antioxidant defense; cardiovascular complications; kardiovaskularne komplikacije; oksidativni stres; oxidative stress; tip 2 diabetes mellitusa; type 2 diabetes mellitus
• ISSN: 1452-8258; 1452-8266
• DOI: 10.2478/v10011-007-0002-z

It is well established that type 2 diabetes mellitus is associated with highly increased risk of coronary heart disease, cardiovascular disease (CVD), and total mortality. CVD is the leading cause of death of people with diabetes. The aim of our study was to test the effect of type and duration of cardiovascular complications on antioxidant parameter values: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status in patients with type 2 diabetes mellitus and manifested cardiovascular complications. Out of 100 subjects included in the study, 69 subjects were type 2 diabetic patients with cardiovascular complications and 31 age-matched controls. Statistical data processing revealed significantly lower antioxidant defense (p<0.001) in patients with type 2 diabetes and cardiovascular complications manifested as coronary artery disease (CAD), hypertension (HTA) and myocardial infarction experienced in the previous 8 years (AMI). The type 2 diabetics with longer history of diabetes and coronary artery disease had higher fasting glucose values, higher GR activity, but lower TAS and SOD activity (p<0.05). Fasting glucose levels were in negative correlation with SOD and GPx activities in the subgroups of diabetics with severe cardiovascular complications (CAD+AMI, CAD+AMI+ HTA) (p<0.05).
Poznato je od ranije da pacijenti sa tipom 2 diabetes mellitusa imaju povećan rizik za nastanak koronarne bolesti srca, kardiovaskularnih bolesti i mortaliteta. Kardiovaskularne bolesti predstavljaju vodeći uzrok smrti u pacijenata s tipom 2 dijabetesa. Cilj ovog rada bio je da se ispita uticaj vrste i dužine trajanja kardiovaskularnih komplikacija na vrednost antioksidativnih parametara: superoksid dismutaze (SOD), glutation peroksidaze (GPx), glutation reduktaze (GR) i ukupnog antioksidantnog statusa (TAS) pacijenata sa tipom 2 diabetes mellitusa i sa izraženim kardiovaskularnim komplikacijama. Ispitano je 100 ispitanika, među njima 69 obolelih od dijabetesa tipa 2 sa prisutnim kardiovaskularnim komplikacijama i 31 zdrav ispitanik. Statističkom obradom podataka dobijeno je da pacijenti s tipom 2 dijabetesa i sa izraženim kardiovaskularnim komplikacijama u vidu koronarne bolesti srca (KB), hipertenzije (HTA) i preležanog akutnog infarkta miokarda (AIM) u poslednjih 8 godina, imaju značajno niže vrednosti antioksidativnih parametara (p<0,001) u odnosu na zdrave ispitanike. Dijabetičari tipa 2 koji imaju duže vremena dijabetes i koronarnu bolest imaju i veće vrednosti glukoze, višu aktivnost GR, ali i niže koncentracije TAS-a i niže aktivnosti SOD-a (p<0,05). Jutarnja koncentracija glukoze negativno korelira sa aktivnostima SOD-a i GPx-a u podgrupama dijabetičara sa ozbiljnijim kardiovaskularnim komplikacijama (KB+AIM; KB+HTA+AIM) (p<0,05).