Modulation of the transcellular metabolism of 12(S)HETE by 10-11 reductase activity in cultured rat aortic smooth muscle cells

Cultured rat aortic smooth muscle cells (SMC) metabolize 12(S)hydroxyeicosatetraenoic acid (12(S)HETE) by two different pathways; beta-oxidation leading to 16:3(8-OH), and 10-11 reductase activity producing 20:3(12-OH) which is beta-oxidized to 16:2(8-OH). In this work, we demonstrate that 10-11 red...

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Bibliographic Details
Published in:	Prostaglandins, leukotrienes and essential fatty acids Vol. 51; no. 3; p. 187
Main Authors:	Berard, A, Lacape, G, Daret, D, Larrue, J
Format:	Journal Article
Language:	English
Published:	Scotland 01-09-1994
Subjects:	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Animals Aorta Blood Physiological Phenomena Cattle Cell Division Cells, Cultured Chromatography, High Pressure Liquid Culture Media - pharmacology Hydroxyeicosatetraenoic Acids - metabolism Membrane Lipids - metabolism Muscle Proteins - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Oxidoreductases - metabolism Phospholipids - metabolism Rats
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