The Effect of Temporary Hemiepiphyseal Stapling on the Growth Plate: A Radiologic and Immunohistochemical Study in Rabbits

• Published in: Journal of pediatric orthopaedics Vol. 25; no. 3; pp. 336 - 341
• Main Authors: Aykut, Umit S, Yazici, Muharrem, Kandemir, Utku, Gedikoglu, Gokhan, Aksoy, M Cemalettin, Cil, Akin, Surat, Adil
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 01-05-2005; Lippincott
• Subjects: Animals; Biological and medical sciences; Bone Development - physiology; Diseases of the osteoarticular system; Growth Plate - diagnostic imaging; Growth Plate - pathology; Growth Plate - physiopathology; Leg Length Inequality - etiology; Male; Medical sciences; Rabbits; Radiography; Surgical Stapling - adverse effects; Tibia - diagnostic imaging; Tibia - pathology; Tibia - physiopathology; Time Factors; Immunohistochemistry; Proximal; temporary; Growth; Check; Rabbit; Diaphysis; Prevention; Stapling; Regulation(control); Tibia; Skeleton; Staple; Long bone; Periosteum; Method; hemiepiphyseal; Lagomorpha; Ablation; Geometry; Anatomic pathology; Vertebrata; Mammalia; Epiphyseal cartilage; Animal; End; growth plate; Maturity
• ISSN: 0271-6798; 1539-2570
• DOI: 10.1097/01.bpo.0000152906.23669.d8

The purpose of this study was to investigate the effect of temporary hemiepiphyseal stapling on the bone geometry and proliferative activity of the physis in immature rabbits. Proximal medial epiphyseal stapling of the right tibia was performed in 46 6-week-old New Zealand white rabbits. The rabbits were assigned randomly into two groups. In group 1, the staples were inserted extraperiosteally and the rabbits were killed at the end of 3 weeks. In group 2, the staples were fixed subperiosteally (group IIA) or extraperiosteally (group IIB), the staples were removed at the end of 3 weeks, and the rabbits were killed at the end of 6 weeks. The articular line-diaphysis angle (ALDA) was significantly increased with 3 weeks of stapling. After the removal of staples, while ALDA continued to worsen in group IIA, it improved in group IIB. Bone was observed to bridge the physis in group IIA. However, the proliferative activity of the physis continued. Temporary hemiepiphyseal stapling is a safe and effective method for control of physeal growth of long bones before skeletal maturity. However, it is of paramount importance not to disturb the periosteum during stapling.