Ultra-trace level voltammetric sensor for MB in human plasma based on a carboxylic derivative of Calix[4]resorcinarene capped silver nanoparticles

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 107; pp. 81 - 92
• Main Authors: Rehman Umar, Abdul, Hussain, Kashif, Aslam, Zara, Anwar Ul Haq, Muhammad, Muhammad, Haji, Sirajuddin, Raza Shah, Muhammad
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25-03-2022; 한국공업화학회
• Subjects: Calixresorcinarene; Human plasma; MB drug; Silver nanoparticles; Voltammetric sensor; 화학공학; Voltammetric sensor; MB drug; Calixresorcinarene; Human plasma; Silver nanoparticles
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2021.11.024

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•Synthesis of modified Resorcinarene and its capping of silver nanoparticles (AgNPs).•Application of AgNPs for low level voltammetric sensing of Methylene blue (MB) drug.•Use of developed sensor for MB determination in human blood plasma.
This work was initiated by synthesizing a carboxylic derivative of Calix[4]resorcinarene through a three step protocol confirmed by proton nuclear magnetic resonance (1H NMR) spectroscopy and Electrospray ionization mass spectroscopy (ESI-MS). As synthesized derivative, was used as reducing and capping material for the fabrication of small and stable silver nanoparticles (AgNPs) in aqueous medium under the combined influence of dilute alkali and heat at 90 °C. These nanoparticles were referred as KM20-AgNPs. Techniques used for characterization of AgNPs include UV–Visible (UV–Vis) spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, atomic force microscopy (AFM), dynamic light scattering (DLS) and zeta potential analyzer (ZPA). The finally produced KM20-AgNPs were recognized as highly sensitive and extremely selective voltammetric sensor for low level detection of methylene blue drug in the linear working range of 1–30 nM with limit of detection (LOD) and limit of quantification (LOQ) as 0.16 nM and 0.53 nM respectively. The developed sensor was successfully used for sensing of MB in human blood plasma.