Massive amoxycillin crystalluria causing anuric acute renal failure

The authors report the case of a 45-year-old woman admitted for pneumonia who presented anuric acute renal failure after 12 days of intravenous amoxycillin-clavulanate treatment. Acute renal failure resolved rapidly and completely after antibiotic withdrawal. Analysis of the first post-anuric urine...

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Bibliographic Details
Published in:	Clinical nephrology Vol. 59; no. 6; p. 455
Main Authors:	Labriola, L, Jadoul, M, Daudons, M, Pirson, Y, Lambert, M
Format:	Journal Article
Language:	English
Published:	Germany 01-06-2003
Subjects:	Acute Kidney Injury - chemically induced Amoxicillin - urine Amoxicillin-Potassium Clavulanate Combination - adverse effects Amoxicillin-Potassium Clavulanate Combination - therapeutic use Anuria - chemically induced Crystallization Drug Therapy, Combination - adverse effects Drug Therapy, Combination - therapeutic use Female Humans Middle Aged Pneumonia - drug therapy
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Summary:	The authors report the case of a 45-year-old woman admitted for pneumonia who presented anuric acute renal failure after 12 days of intravenous amoxycillin-clavulanate treatment. Acute renal failure resolved rapidly and completely after antibiotic withdrawal. Analysis of the first post-anuric urine specimen showed many crystals. Infrared spectrophotometry revealed that the crystals were composed of trihydrated amoxycillin. The possibility of intrarenal obstruction due to massive drug crystalluria should not be overlooked in the face of abrupt anuria.
ISSN:	0301-0430
DOI:	10.5414/CNP59455